The advent of new drug therapies has resulted in a need for drug delivery that can deal\nwith increased drug concentration and viscosities. Needle-free liquid jet injection has shown great\npotential as a platform for administering some of these revolutionary therapies. This investigation\nexplores the detonative combustion phenomenon in gases as a simple and efficient means of powering\nneedle-free liquid jet injection systems. A preliminary, large-scale prototype injector was designed\nand developed. In contrast with the widely used air-powered and electrical driven needle-free\ninjectors, the proposed detonation-driven mechanism provides equivalent liquid jet evolution and\nperformance but can efficiently provide a controllable power source an order magnitude higher in\nstrength by varying combustible mixtures and initial conditions. The simplicity and power output\nassociated with this concept aid in improving current needle-free liquid injector design, especially for\ndelivery of high volume, high viscosity drugs, including monoclonal antibodies, which target precise\nlocations in skin tissue.
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